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Hemojuvelin is essential for transferrin-dependent and -independent hepcidin expression in mice.
Haematologica. 2011 Oct 11;
Authors: Bartnikas TB, Fleming MD
Abstract
Here we investigate the regulation of hepcidin, a hormone that inhibits dietary iron absorption and macrophage iron recycling, by the serum iron-binding protein transferrin. Mice deficient in transferrin (Tfhpx/hpx) and hemojuvelin (Hjv-/-), a gene mutated in juvenile hemochromatosis, a disease of hepcidin deficiency and iron overload, were generated. While Tfhpx/hpx Hjv+/+ and Tfhpx/hpx Hjv-/- phenotypes did not differ markedly, transferrin treatment and RBC transfusions robustly increased hepcidin levels in Tfhpx/hpx Hjv+/+ but not Tfhpx/hpx Hjv-/- mice. These results suggest that, while hemojuvelin is not essential for the establishment or maintenance of hepcidin deficiency in transferrin-deficient mice, hemojuvelin is essential for transferrin-dependent and independent hepcidin expression in conditions of iron overload.
PMID: 21993681 [PubMed - as supplied by publisher] Read more |
