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BMPER is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice.
J Biol Chem. 2011 Dec 5;
Authors: Patel N, Masaratana P, Diaz-Castro J, Latunde-Dada O, Qureshi A, Lockyer P, Jacob M, Arno M, Matak P, Mitry R, Hughes R, Dhawan A, Patterson C, Simpson RJ, McKie AT
Abstract
The BMP/SMAD4 pathway has major effects on liver hepcidin levels. Bone morphogenetic protein-binding endothelial cell precursor-derived regulator (Bmper), a known regulator of BMP signalling, was found to be over expressed at the mRNA and protein level in liver of genetically hypotransferrinanemic mice (Trfhpx/hpx). Soluble BMPER peptide inhibited BMP2 and BMP6-dependent hepcidin promoter activity in both HepG2 and HuH7 cells. These effects correlated with reduced cellular levels of pSMAD1/5/8. Addition of BMPER peptide to primary human hepatocytes abolished the BMP2-dependent increase in hepcidin mRNA, while injection of Bmper peptide into mice resulted in reduced liver hepcidin and increased serum iron levels. Thus Bmper may play an important role in suppressing hepcidin production in hypotransferrinemic mice.
PMID: 22144676 [PubMed - as supplied by publisher] Read more |
