Tomas Ganz is a co-founder of Intrinsic LifeSciences. He holds a Ph.D. in Applied Physics from the California Institute of Technology and an M.D. from UCLA. Tom trained in Internal Medicine and Pulmonary Critical Care at UCLA, and has been on the faculty of UCLA since 1983, now as a Professor of Medicine and Pathology.
He participated in the founding of Intrabiotics, and has consulted for major biotechnology and pharmaceutical companies including Xenon, Ceragenix, Isis, Fibrogen and Hoffman-La Roche. He has studied the biology of host defense peptides since 1983, discovered the iron regulatory peptide hepcidin in the 1990s, and has made major contributions to the revolution in iron biology and the understanding of iron-related disease that has taken place during the last decade. In 2005, Tom received the Marcel Simon Award from the International BioIron Society (IBIS) for “Contributions to the knowledge of iron metabolism and its disorders”. He has published more than 200 peer-reviewed articles.
Tomas Ganz’s Selected Publications:
- • Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice.
- • Hepcidin and iron regulation, ten years later.
- • Hepcidin and disorders of iron metabolism.
- • In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2.
- • Immunoassay for human serum hepcidin.
- • The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study.
- • Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin.
- • Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs.
- • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.
- • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein.
- • Hepcidin, a urinary antimicrobial peptide synthesized in the liver.
For the full list of publications, click here http://www.ncbi.nlm.nih.gov/pubmed?term=Ganz%20T%20AND%20Los%20Angeles