Hepcidin Research and Publications

Intrinsic LifeSciences Publications

References

A mouse model of juvenile hemochromatosis

Huang FW, Pinkus JL, Pinkus GS, Fleming MD, Andrews NC.

A mutation in the TMPRSS6 gene encoding a transmembrane serine protease that suppresses hepcidin production in familial iron deficiency anemia refractory to oral iron

Melis MA, Cau M, Congiu R, Sole G, Barella S, Cao A, Westerman M, Cazzola M, Galanello R.

A New Mouse Liver specific Gene Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin Is Overexpressed during Iron Overload

Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loréal O.

A Portuguese patient homozygous for the -25GA mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron

Porto G, Roetto A, Daraio F, Pinto JP, Almeida S, Bacelar C, Nemeth E, Ganz T, Camaschella C.

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

Wang RH, Li C, Xu X, Zheng Y, Xiao C, Zerfas P, Cooperman S, Eckhaus M, Rouault T, Mishra L, Deng CX.

An immunoassay for human serum hepcidin at last

Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M.

Anti-interleukin 6 receptor antibody tocilizumab reduces the level of serum hepcidin in patients with multicentric Castleman’s disease

Kawabata H, Tomosugi N, Kanda J, Tanaka Y, Yoshizaki K, Uchiyama T.

Bass hepcidin synthesis solution structure antimicrobial activities and synergism and in vivo hepatic response to bacterial infections

Lauth X, Babon JJ, Stannard JA, Singh S, Nizet V, Carlberg JM, Ostland VE, Pennington MW, Norton RS, Westerman ME.

Blood First Edition Paper, prepublished online August 8, 2008

Tomas Ganz, Gordana Olbina, Domenico Girelli, Elizabeta Nemeth, and Mark Westerman

Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice

Viatte L, Nicolas G, Lou DQ, Bennoun M, Lesbordes-Brion JC, Canonne-Hergaux F, Schönig K, Bujard H, Kahn A, Andrews NC, Vaulont S.

Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin

Lin L, Goldberg YP, Ganz T.

Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System

Tomosugi N, Kawabata H, Wakatabe R, Higuchi M, Yamaya H, Umehara H, Ishikawa I.

Expression of hepcidin in hereditary hemochromatosis evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron

Gehrke SG, Kulaksiz H, Herrmann T, Riedel HD, Bents K, Veltkamp C, Stremmel W.

Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis

Kawabata H, Fleming RE, Gui D, Moon SY, Saitoh T, O’Kelly J, Umehara Y, Wano Y, Said JW, Koeffler HP.

First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin

Wallace DF, Summerville L, Lusby PE, Subramaniam VN.

Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation

Roy CN, Mak HH, Akpan I, Losyev G, Zurakowski D, Andrews NC.

Hepcidin compared with prohepcidin an absorbing story

Frazer DM, Anderson GJ.

Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia

Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen OE, Ganz T.

Hepcidin expression in the liver relatively low level in patients with chronic hepatitis C

Fujita N, Sugimoto R, Takeo M, Urawa N, Mifuji R, Tanaka H, Kobayashi Y, Iwasa M, Watanabe S, Adachi Y, Kaito M.

Hepcidin Expression in the Liver Relatively Low Level in

Fujita N, Sugimoto R, Takeo M, Urawa N, Mifuji R, Tanaka H, Kobayashi Y, Iwasa M, Watanabe S, Adachi Y, Kaito M.

Hepcidin in iron overload disorders

George Papanikolaou, Michalis Tzilianos, John I. Christakis, Dionisios Bogdanos, Konstantina Tsimirika, Julie MacFarlane, Y. Paul Goldberg, Nikos Sakellaropoulos, Tomas Ganz, and Elizabeta Nemeth

Hepcidin is decreased in TFR2 hemochromatosis

Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C.

Hepcidin levels in humans are correlated with hepatic iron stores hemoglobin levels and hepatic function

Détivaud L, Nemeth E, Boudjema K, Turlin B, Troadec MB, Leroyer P, Ropert M, Jacquelinet S, Courselaud B, Ganz T, Brissot P, Loréal O.

Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis

Vokurka M, Krijt J, Sulc K, Necas E.

Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T.

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

Park CH, Valore EV, Waring AJ, Ganz T.

Hepcidin—A Potential Novel Biomarker for Iron Status in Chronic Kidney Disease

Zaritsky J, Young B, Wang HJ, Westerman M, Olbina G, Nemeth E, Ganz T, Rivera S, Nissenson AR, Salusky IB.

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T.

Impaired intestinal iron absorption in Crohns disease correlates with disease activity and markers of inflammation

Semrin G, Fishman DS, Bousvaros A, Zholudev A, Saunders AC, Correia CE, Nemeth E, Grand RJ, Weinstein DA.

Inappropriate expression of hepcidin is associated with iron refractory anemia implications for the anemia of chronic disease

Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC.

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S.

LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

Krause A, Neitz S, Mägert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, Adermann K.

Liver iron concentrations and urinary hepcidin in beta-thalassemia

Origa R, Galanello R, Ganz T, Giagu N, Maccioni L, Faa G, Nemeth E.

Mass spectrometry-based hepcidin measurements in serum and urine analytical aspects and clinical implications

Kemna EH, Tjalsma H, Podust VN, Swinkels DW.

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, Christakis J, Loukopoulos D, Camaschella C.

Novel urine hepcidin assay by mass spectrometry

Kemna E, Tjalsma H, Laarakkers C, Nemeth E, Willems H, Swinkels D.

Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease

Zoller H, McFarlane I, Theurl I, Stadlmann S, Nemeth E, Oxley D, Ganz T, Halsall DJ, Cox TM, Vogel W.

Regulation of hepcidin transcription by interleukin-1 and interleukin-6

Lee P, Peng H, Gelbart T, Wang L, Beutler E.

Regulation of iron homeostasis in anemia of chronic disease and iron deficiency

Theurl I, Aigner E, Theurl M, Nairz M, Seifert M, Schroll A, Sonnweber T, Eberwein L, Witcher DR, Murphy AT, Wroblewski VJ, Wurz E, Datz C, Weiss G.

Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin

Drakesmith H, Schimanski LM, Ormerod E, Merryweather-Clarke AT, Viprakasit V, Edwards JP, Sweetland E, Bastin JM, Cowley D, Chinthammitr Y, Robson KJ, Townsend AR.

Results of the first international round robin for the quantification of urinary

Kroot JJ, Kemna EH, Bansal SS, Busbridge M, Campostrini N, Girelli D, Hider RC, Koliaraki V, Mamalaki A, Olbina G, Tomosugi N, Tselepis C, Ward DG, Ganz T, Hendriks JC, Swinkels DW.

Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young women

Young MF, Glahn RP, Ariza-Nieto M, Inglis J, Olbina G, Westerman M, O’Brien KO.

Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5′-UTR of the HAMP gene

Matthes T, Aguilar-Martinez P, Pizzi-Bosman L, Darbellay R, Rubbia-Brandt L, Giostra E, Michel M, Ganz T, Beris P.

Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B, Sirito M, Sawadogo M, Kahn A, Vaulont S.

Suppression of hepcidin during anemia requires erythropoietic activity

Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S.

Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis

Lesbordes-Brion JC, Viatte L, Bennoun M, Lou DQ, Ramey G, Houbron C, Hamard G, Kahn A, Vaulont S.

The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major

Kattamis A, Papassotiriou I, Palaiologou D, Apostolakou F, Galani A, Ladis V, Sakellaropoulos N, Papanikolaou G.

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia hypoxia and inflammation

Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, Beaumont C, Kahn A, Vaulont S.

The iron exporter ferroportinSlc40a1 is essential for iron homeostasis

Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, Andrews NC.

The molecular basis of ferroportin-linked hemochromatosis

De Domenico I, Ward DM, Nemeth E, Vaughn MB, Musci G, Ganz T, Kaplan J.

The N-terminus of hepcidin is essential for its interaction with ferroportin structure-function study

Nemeth E, Preza GC, Jung CL, Kaplan J, Waring AJ, Ganz T.

The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis

Hunter HN, Fulton DB, Ganz T, Vogel HJ.

Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS

Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D.