Intrinsic Hepcidin IDx™ ELISA Kit

Description

The Intrinsic Hepcidin IDx™ ELISA kit is a monoclonal antibody-based assay that binds with high affinity to the N-terminus of hepcidin-25. This antibody also binds low abundance, N-terminus isomers of hepcidin-25 with lower affinities.

Hepcidin is a 25-amino acid peptide hormone that regulates dietary iron absorption from the duodenum, controls recycling of senescent erythrocyte iron by macrophages, and manages iron transport from hepatocytes into plasma. Hepcidin is positively regulated by plasma iron and IL-6 (inflammation, infection) and is suppressed by erythropoiesis via erythroferrone. Abnormally low serum hepcidin is associated with iron deficiency anemia (IDA) and hereditary hemochromatosis, and high serum hepcidin can lead to iron sequestration and to anemia of inflammation (anemia of chronic disease) observed in chronic kidney disease (CKD), rheumatoid arthritis (RA), various cancers, and iron refractory iron deficiency anemia (IRIDA). Hepcidin levels have been shown to be useful in predicting response to oral iron therapy.

U.S. Pat. No. 9,657,098; NZ Pat. No. 631098; Pat. Pending in the US and abroad.

ICE-007 Product Insert v6

Questions? Please email us: custserv@intrinsiclifesciences.com

SKU: ICE-007 Category:

$838.00

Quantity
96 Tests (1x96 well)
Application
ELISA
Method
Competitive
Antibody Type
Monoclonal
Target Species
Human
Analyte
Hepcidin-25
Sample Type
Serum and Plasma
Recommended Sample Volume
20 μl
Standard Range
2.5 - 1000 ng/ml
Regulatory Status
Research Use Only. Not for use in diagnostic procedures.
Storage Requirements
2 - 8 C
Shipping Condition
Ambient

Description

The Intrinsic Hepcidin IDx™ ELISA kit is a monoclonal antibody-based assay that binds with high affinity to the N-terminus of hepcidin-25. This antibody also binds low abundance, N-terminus isomers of hepcidin-25 with lower affinities.

Hepcidin is a 25-amino acid peptide hormone that regulates dietary iron absorption from the duodenum, controls recycling of senescent erythrocyte iron by macrophages, and manages iron transport from hepatocytes into plasma. Hepcidin is positively regulated by plasma iron and IL-6 (inflammation, infection) and is suppressed by erythropoiesis via erythroferrone. Abnormally low serum hepcidin is associated with iron deficiency anemia (IDA) and hereditary hemochromatosis, and high serum hepcidin can lead to iron sequestration and to anemia of inflammation (anemia of chronic disease) observed in chronic kidney disease (CKD), rheumatoid arthritis (RA), various cancers, and iron refractory iron deficiency anemia (IRIDA). Hepcidin levels have been shown to be useful in predicting response to oral iron therapy.

U.S. Pat. No. 9,657,098; NZ Pat. No. 631098; Pat. Pending in the US and abroad.

ICE-007 Product Insert v6

Questions? Please email us: custserv@intrinsiclifesciences.com

Additional information

Weight 10 oz
Dimensions 7 x 6.0 x 4.0 in
0

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