Hepcidin Murine-Compete™ ELISA Kit

Description

The Intrinsic LifeSciences Hepcidin-Murine Compete™ ELISA is designed for quantification of hepcidin-1 (hepc-1) in murine serum and urine. Murine hepcidin-2 (hepc-2) is not detected and does not interfere with hepc-1 measurements using this ELISA. This kit does not contain mercaptoethanol, azide- or mercury-based preservatives.

Hepcidin was discovered to be an antimicrobial peptide produced in the liver and was identified as the peptide hormone that regulates extracellular iron in response to changes in dietary and systemic iron load, anemia, hypoxia, erythropoiesis, and inflammation. Hepcidin inhibits cellular iron efflux by binding to and inducing degradation of the sole known iron channel, ferroportin. Synthetic hepcidin injected into mice binds to ferroportin-rich tissues and rapidly lowers serum iron levels. Data on the normal ranges of circulating levels of the hepcidin-1 protein in common mouse model strains (e.g. Bl/6) are not available currently. Murine hepc-1 peptide levels will scale closely with dietary iron concentration of the feed and will correlate with hepc-1 gene expression measured by qPCR.

HMC-001 Product Insert

Questions? Please email us: custserv@intrinsiclifesciences.com

SKU: HMC-001 Category:

$738.00

Quantity
96 Tests (12x8 strip well)
Application
ELISA
Method
Competitive
Antibody Type
Polyclonal
Target Species
Mouse
Analyte
Hepcidin-1
Sample Type
Murine serum and urine
Recommended Sample Volume
10 μl
Standard Range
0.14 - 1000 ng/ml
Regulatory Status
Research Use Only. Not for use in diagnostic procedures.
Storage Requirements
2 - 8 C
Shipping Condition
Ambient
References

1. Pasricha, SR et al. 2017. Nature Communications, 8:403. DOI: 10.1038/s41467-017-00500-z

2. Guo, W. 2016. Endocrinology 157:2937-2946

3. Schmidt, P et al. 2015. Am. J. Hematol. 90:310-313.

4. Gutschow, P et al. 2015. Haematologica 100(2): 167-177.

Description

The Intrinsic LifeSciences Hepcidin-Murine Compete™ ELISA is designed for quantification of hepcidin-1 (hepc-1) in murine serum and urine. Murine hepcidin-2 (hepc-2) is not detected and does not interfere with hepc-1 measurements using this ELISA. This kit does not contain mercaptoethanol, azide- or mercury-based preservatives.

Hepcidin was discovered to be an antimicrobial peptide produced in the liver and was identified as the peptide hormone that regulates extracellular iron in response to changes in dietary and systemic iron load, anemia, hypoxia, erythropoiesis, and inflammation. Hepcidin inhibits cellular iron efflux by binding to and inducing degradation of the sole known iron channel, ferroportin. Synthetic hepcidin injected into mice binds to ferroportin-rich tissues and rapidly lowers serum iron levels. Data on the normal ranges of circulating levels of the hepcidin-1 protein in common mouse model strains (e.g. Bl/6) are not available currently. Murine hepc-1 peptide levels will scale closely with dietary iron concentration of the feed and will correlate with hepc-1 gene expression measured by qPCR.

HMC-001 Product Insert

Questions? Please email us: custserv@intrinsiclifesciences.com

Additional information

Weight 13 oz
Dimensions 7.0 x 6.0 x 4.0 in

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